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KMID : 1123920040180020599
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 2 p.599 ~ p.605
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The Effect of Sopungchungyoung-tang on Activity of CD4 T cell
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Choi Young-Jin
Kang Hee
Myung Eu-Gene
Shim Bum-Sang
Choi Seung-Hoon
Kim Sung-Hoon
Ahn Kyoo-Seok
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Abstract
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Sopungchungyoung-tang (SCT) has been widely used in Korea as a treatment of atopic dermatitis. SCT consists of Talcum, Rehmannia glutinosa, Angelica sinensis, Paeonia lactiflora, Cnidium officinale, Ledebouriella divaricata, Schizonepeta tenuifolia, Scutellaria baicalensis, Glycyrrhiza uralensis, Mentha arvensis, Cordyceps cicadae. We examined the immunological effect of SCT in vitro. We studied about the effect of SCT on Th cells’ differentiation. In the case of CD4 T cells under neutral condition where there was only rIL-2 stimulus, SCT inhibited IFN-γ secretion by 70-80 %. Likewise, SCT also inhibited the IL-4 secretion of neutral Th cells by 85-90 %. We also experimented with the polarized Th1 cells/ Th2 cells and their production of IFN-γ and IL-4, respectively. There also were inhibitory effects on the polarized cells like there was on neutral cells, they were not as strong on the polarized cells. Under Th1 polarized condition, SCT acted dose-dependently, while in Th2 cells, the IL-4 production was inversely proportional to the doses of SCT. From the current study, it can be concluded that SCT exerts inhibitory effects on cytokine production without interfering with immune cells’ activity. The result that SCT inhibits IFN-γ and IL-4 confirms that it does have a effect on immunomodulation.
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KEYWORD
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Sopungchungyoung-tang(SCT), CD4 T cell, INF-γ, IL-4
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